【公開日：2025.06.10】【最終更新日：2025.05.13】
課題データ / Project Data
課題番号 / Project Issue Number
24UT0116
利用課題名 / Title
Scintillating Nanoparticles for Cancer cell therapy
利用した実施機関 / Support Institute
東京大学 / Tokyo Univ.
機関外・機関内の利用 / External or Internal Use
内部利用（ARIM事業参画者以外）/Internal Use (by non ARIM members)
技術領域 / Technology Area
【横断技術領域 / Cross-Technology Area】（主 / Main）計測・分析/Advanced Characterization（副 / Sub）-
【重要技術領域 / Important Technology Area】（主 / Main）次世代バイオマテリアル/Next-generation biomaterials（副 / Sub）次世代ナノスケールマテリアル/Next-generation nanoscale materials
キーワード / Keywords
DDSマテリアル/ DDS material,ナノ粒子/ Nanoparticles,電子顕微鏡/ Electronic microscope
利用者と利用形態 / User and Support Type
利用者名（課題申請者）/ User Name (Project Applicant)
Maiti Debabrata
所属名 / Affiliation
東京大学大学院工学系研究科マテリアル工学専攻
共同利用者氏名 / Names of Collaborators in Other Institutes Than Hub and Spoke Institutes
ARIM実施機関支援担当者 / Names of Collaborators in The Hub and Spoke Institutes
寺西亮佑
利用形態 / Support Type
（主 / Main）技術補助/Technical Assistance（副 / Sub）-
利用した主な設備 / Equipment Used in This Project
報告書データ / Report
概要（目的・用途・実施内容）/ Abstract (Aim, Use Applications and Contents)
Tumor hypoxia represents a major challenge to achieving successful therapy outcomes with photodynamic therapy (PDT). We hypothesized that systemic loading of dual porphyrins, protoporphyrin IX as a photosensitizer and hemin as an oxygen generator, onto Eu-doped NaYF4 scintillator (NaYF4:Eu), collectively terms as Eu-PPIX@Hemin, could enhance the activity of X-ray mediated PDT. With help of ARIM japan, we confirmed the successful synthesis of core inorganic materials, NaYF4:Eu.
実験 / Experimental
1. Bright-field transmission electron microscopy (TEM) image of NaYF4:Eu and their size distribution. 2. High-resolution TEM image of NaYF4:Eu. 3. Scanning transmission electron microscopy image of NaYF4:Eu. 4. Energy-dispersive X-ray spectroscopy (EDS) analysis of NaYF4:EuAll experiments were performed in JEM-2800(UT-006).
結果と考察 / Results and Discussion
The results of TEM observation and elemental analysis by EDS confirmed that NaYF4 is doped with Eu. We successfully synthesized ~8 nm sized NaYF4:Eu and ultimately applied the inorganic nanoparticles to produce ROS for cancer therapy.
図・表・数式 / Figures, Tables and Equations
(A) Bright-field transmission electron microscopy (TEM) image of NaYF4:Eu. (B) Size distribution histogram of NaYF4:Eu. (C) High-resolution TEM imageof NaYF4:Eu. (D) Scanning transmission electron microscopy image of NaYF4:Eu. (E) Energy-dispersive X-ray spectroscopy (EDS) analysis of NaYF4:Eu, confirmingthe existence of Y and Eu in the sample and the non-doped “blank spot.”
その他・特記事項（参考文献・謝辞等） / Remarks(References and Acknowledgements)
The results was published in ChemBioChem (2024, e202400838), accepted in Dec 4th, 2024.
成果発表・成果利用 / Publication and Patents
論文・プロシーディング（DOIのあるもの） / DOI (Publication and Proceedings)
-
Debabrata Maiti, Dual Porphyrin‐Loaded Scintillating Nanoparticles Enhanced Photodynamic Therapy in Hypoxic Cancer Cells under X‐ray Irradiation, ChemBioChem, 26, (2024).
DOI: doi.org/10.1002/cbic.202400838
口頭発表、ポスター発表および、その他の論文 / Oral Presentations etc.
特許 / Patents
特許出願件数 / Number of Patent Applications：0件
特許登録件数 / Number of Registered Patents：0件